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  Home > Uses of Aspirin > Cardiovascular Disease > Aspirin in Cardiovascular Disease: Aspirin and Stroke
Uses of Aspirin A Man with a Headache



Cardiovascular Disease
Strokes
Pregnancy Complications
Cancer
Diabetes
Dementia



Aspirin and Stroke

Long-term prophylaxis with aspirin after an ischaemic stroke or transient ischaemic event (TIA) reduces the incidence of further vascular events by about 22%.37

Reduction of mortality by aspirin during the acute phase of a stroke has recently been examined in two very large randomised trials. 38,39 aspirin, given during the first two to four weeks, led to an additional saving of about 1 death per 100 patients - ‘a modest but worthwhile improvement’. (40)

aspirin is not however to be recommended in either cardio-embolic stroke, or haemorrhagic stroke. Anticoagulation is the treatment of choice in the first, and the control of blood pressure in the second.

The differential diagnosis between these and an ischaemic lesion is of course difficult. If computerised tomography (a CT scan) can be performed and if this indicates an ischaemic lesion, aspirin should be given as early as possible, but otherwise it is best witheld during the acute phase of a cerebral lesion.

1897 - Hoffman produced acetyl salicylic acid

1974 - First randomised trial of aspirin and MI reported

1980 - FDA approves the use of aspirin after a stroke

1985 - FDA approves aspirin after heart attack

1996 - FDA approves aspirin for use in suspected MI

 

 
Cardiovascular Disease
The Medicinal Use of Salicylates
The Synthesis of Aspirin
Platelets and Thrombosis
Aspirin and platelets
Aspirin and Coronary Thrombosis
Aspirin and Stroke
Aspirin in Primary Prevention
‘Early’ and ‘Immediate’ Aspirin
Formulations of Aspirin
Undesirable Side Effects
The Dose for Prophylaxis
The Cost of Prophylaxis
Alternatives to Aspirin
Possible New Uses of Aspirin
Recommendations
References