Guidelines for Cardiovascular Disease

March 2018

UK GUIDELINES

Primary prevention

NICE CKS Antiplatelet treatment: Primary prevention of CVD Last revised October 2015 “Do not routinely prescribe antiplatelet treatment for the primary prevention of cardiovascular disease (CVD).” It does however discuss the pros and cons and cautions for prescribing antiplatelet therapy for those with high blood pressure.

SIGN 149 Risk estimation and the prevention of cardiovascular disease does not recommend aspirin for primary prevention of CVD (Published 2017).

JBS 3 2014 does not recommend aspirin for those at higher risk of CVD e.g. diabetics to use aspirin for primary prevention of CVD.

SECONDARY PREVENTION

NICE CKS Antiplatelet treatment: secondary prevention of CVD guidelines (last revised 2015) state;

“Antiplatelet treatment should be prescribed for the secondary prevention of cardiovascular events in people with:

  • Angina
  • A previous MI
  • A previous stroke or TIA
  • Peripheral Arterial disease
  • Atrial Fibrillation – although anticoagulants are normally used.”

SIGN 148 Acute coronary syndrome (April 16) section 4.4 p 13 recommend the use of aspirin on its own (e.g. self-administered or by ambulance staff) or in combination with other anticoagulants.  

SIGN 147 Management of chronic heart failure (March 2016) section 5.11 p 26 “No firm evidence to supports the use of any antithrombotic therapy in patients with HF-REF in sinus rhythm.”

SIGN 96 management of stable angina is currently being updated and is expected Spring 2018.

NICE CG68 July 2008 (last updated: March 2017) Stroke and transient ischaemic attack in over 16s: diagnosis and initial management. State:

1.4.2.1 “ All people presenting with acute stroke who have had a diagnosis of primary intracerebral haemorrhage excluded by brain imaging should, as soon as possible but certainly within 24 hours, be given :

  • aspirin 300 mg orally if they are not dysphagic or
  • Aspirin 300 mg rectally or by enteral tube if they are dysphagic.”

(See full guidance for further information re aspirin intolerance and allergy updated 2017).

NICE CG68 describes initiating long term antithrombotic treatment after this but is not specific re which drugs.

JBS 3 2014 “Antiplatelet therapy with low dose aspirin (75–100 mg) is recommended indefinitely after myocardial infarction (MI).”

JBS 3 2014 “After acute ischaemic stroke, patients should initially receive 300 mg of aspirin daily for 2 weeks, then be changed to long term clopidogrel 75 mg daily. For patients who have a contraindication or intolerance to clopidogrel, modified release dipyridamole plus aspirin is an alternative. For people who have a contraindication or intolerance to both clopidogrel and aspirin, modified release dipyridamole alone is recommended.”

JBS 3 “For patients with transient ischaemic attacks (TIAs), modified release dipyridamole 200 mg twice daily plus aspirin 75–150 mg daily is an alternative treatment option to clopidogrel. For people who have a contraindication or intolerance to aspirin, modified release dipyridamole alone is an alternative treatment option.”

Atrial fibrillation (AF)

NICE Atrial Fibrillation: management (CG180) (Published 2014 Updated August 2014)  recommends that adults with AF are prescribed newer oral anticoagulants (NOACs) such as apixaban, dabigatran, etexilate, rivaroxaban or a vitamin K antagonist e.g. warfarin rather than aspirin in order to prevent stroke.

SIGN 94 Cardiac arrhythmias in coronary heart disease is currently being updated and is expected Spring 2018.


USA GUIDELINES

PRIMARY PREVENTION OF CARDIOVASCULAR DISEASE 

The U.S. Preventative Services Task Force (USPSTF) was created in 1984 and is an independent, volunteer panel of national experts in preventative and evidence-based medicine.  They use the following to grade their recommendations:

The USPSTF April 2016 recommends low-dose aspirin to prevent cardiovascular disease and colorectal cancer in the following groups:

Grade B Adults age 50 to 59 years with a 10 year CVD risk of greater than 10% who are not at increased risk for bleeding, have a life expectancy of at least 10 years and are willing to take low-dose aspirin for at least 10 years.

Grade C Adults age 60 to 69 years with a 10 year CVD risk of greater than 10% should consider their individual risks versus benefits of long term low dose aspirin. Those who are not at risk of bleeding, have a life expectancy of at least 10 years and are willing to take low-dose aspirin for at least 10 years are more likely to benefit.

“Persons who place a higher value on the potential benefits than the potential harms may choose to initiate low-dose aspirin.”

The USPSTF state that there is insufficient current evidence to assess the balance of benefits versus harms of initiating aspirin for primary prevention of CVD and CRC in adults younger than 50 years or 70 years or older. (Grade I).

https://www.uspreventiveservicestaskforce.org/Page/Document/RecommendationStatementFinal/aspirin-to-prevent-cardiovascular-disease-and-cancer

USPSTF guidelines in development: CVD detection and prevention.

The USPSTF has recommendations on cardiovascular disease (CVD) risk and atrial fibrillation: screening with electrocardiology, cardiovascular disease: risk assessment using non-traditional risk factors and peripheral artery disease (PAD) in adults: screening with ankle brachial index at an evidence review and draft recommendation development stage. These draft guidelines focus on screening and risk assessment but this will help to identify more people who can benefit from preventative therapy. The cardiovascular screening guideline using non-traditional risk factors will include a review of treatment interventions aimed at preventing CVD events. The PAD screening review includes a section on treatment interventions in which it plans to explore antiplatelet therapy.

The American Heart Association (AHA) state (last update March 2017) that;

“Aspirin can help prevent heart attack.”

The AHA recommends;

People at high risk of heart disease should take low-dose aspirin (if told to by their healthcare provider) and that heart attack survivors regularly take low-dose aspirin.

They explain how aspirin helps prevent heart attack and stroke and provide questions for patients to ask their doctor about aspirin.  http://www.heart.org/HEARTORG/Conditions/HeartAttack/PreventionTreatmentofHeartAttack/Aspirin-and-Heart-Disease_UCM_321714_Article.jsp#.WD2DUbR4WhA

National Centre for Biotechnology Information (NCBI), National Library of Medicine (NLM), National Institute of Health (NIH) list an article in the Clinical Medicine and Research (Clin Med Res. 2014: 12(3-4):147-154) which states in its abstract:

“Aspirin therapy is well-accepted as an agent for the secondary prevention of cardiovascular events and current guidelines also define a role for aspirin in primary prevention. In this review, we describe the seminal trials of aspirin use in the context of current guidelines, discuss factors that may influence the effectiveness of aspirin therapy for cardiovascular disease prevention, and briefly examine patterns of use. The body of evidence supports a role for aspirin in both secondary and primary prevention of cardiovascular events in selected population groups, but practice patterns may be suboptimal. As a simple and inexpensive prophylactic measure for cardiovascular disease, aspirin use should be carefully considered in all at-risk adult patients, and further measures, including patient education, are necessary to ensure its proper use.”

They conclude that aspirin despite evidence-based guidelines for both primary prevention in CVD is not optimally used – there is both underuse and overuse. They advocate research to help optimise aspirin use in the groups most likely to benefit.

Launched in 2012, Million HeartsR  (https://millionhearts.hhs.gov/about-million-hearts/index.html) is a national initiative in the USA set up to prevent 1 million heart attacks and strokes by 2017. It is co-lead by The Centers for Disease Control and Prevention and the Centers for Medicare and Medicaid Services Services on behalf of the U.S. Department of Health and Human Services.

Over the next 5 years until 2022 Million HeartsR  plans to build on its experience, expertise and partnerships and seeks commitment to preventing a million CVD events in five years by:

  • Optimizing care for the ABCS of heart health:
  • Aspirin when appropriate
  • Blood pressure control
  • Cholesterol management
  • Smoking cessation

And increase the use of cardiac rehabilitation and healthy living behaviours

The FDA on a consumer advice sheet (last update 30/12/2016) does not currently recommend the use of aspirin for the primary prevention of CVD;

“The FDA has reviewed the available data and does not believe the evidence supports the general use of aspirin for the primary prevention of a heart attack or stroke. In fact, there are serious risks associated with the use of aspirin, including increased risk of bleeding in the stomach and brain, in situations where the benefit of aspirin for primary prevention has not been established.”  https://www.fda.gov/Drugs/ResourcesForYou/Consumers/ucm390574.htm

SECONDARY PREVENTION OF CARDIOVASCULAR DISEASE

American Stroke Association recommends that to prevent another stroke occurring patients create a stroke prevention plan with their  doctor that may include discussing an aspirin regimen or other medications in addition to; managing high blood pressure, reducing blood sugar, eating better, stopping smoking, controlling cholesterol, being active and losing weight. They point out that aspirin is not appropriate for everyone. http://www.strokeassociation.org/STROKEORG/AboutStroke/PreventAnotherStroke/Prevent-Another-Stroke_UCM_496208_SubHomePage.jsp


European Guidelines

PRIMARY PREVENTION OF CARDIOVASCULAR DISEASE 

Key Message: “Antiplatelet therapy is not recommended in individuals free from CVD, due to the increased risk of major bleeding.” ESC 2016

The 2016 European guidelines on CVD prevention review the evidence for antiplatelet therapy in individuals without CVD and conclude that current evidence does not support the use of aspirin in those without CVD due to the risk of a major bleed.

The guidelines state that the results of four major primary prevention trials;

•          Two in patients with diabetes mellitus (ASCEND, ACCEPT-D)

•          One in individuals of advanced age (ASPREE)

•          One in individuals with moderate CV risk (ARRIVE)

are anticipated over the next 5 years. This may alter the current recommendations.

SECON​​​​DARY PREVENTION OF CARDIOVASCULAR DISEASE

The 2016 European Guidelines for CVD prevention make the following recommendations for antiplatelet therapy (see table below). This is a based on a careful appraisal of risks versus benefits of aspirin or other antiplatelet therapy.  The guidelines state that there is a gap in the evidence concerning new antiplatelet drugs in patients with stable coronary artery disease as well as a gap in the understanding about the use of new antiplatelet drugs used in combination with anticoagulation treatment.

Source 2016 European guidelines for cardiovascular disease prevention

Third sector agencies such as the European Heart Network (EHN) play an important role in providing education around clinical data and its interpretation. The EHN’s mission statement is;

“The European Heart Network plays a leading role in the prevention and reduction of cardiovascular diseases, in particular heart disease and stroke, through advocacy, networking, capacity- building and patient support, so that they are no longer a major cause of premature death and disability throughout Europe.”

The EHN’s vision is that;

“Every European has a right to a life free from avoidable cardiovascular diseases.”

One of their objectives in order to achieve this vision is;

  • Gathering and disseminating information relevant to heart health promotion and cardiovascular disease prevention.

The European Stroke Organisation (ESO) aims to

“improve stroke care by providing medical education to healthcare professionals and the lay public. By offering best practice approaches, the ESO’s goal is to harmonise stroke management in Europe. ESO works as the voice of stroke in Europe to bring about political change. The ESO focuses on European level projects while working towards global solutions.”

And is therefore a useful source of information around stroke prevention and management.


CHINESE GUIDELINES

PRIMARY PREVENTION OF CARDIOVASCULAR DISEASE

Cardiovascular disease (CVD) is a growing health burden in China and the primary prevention strategies are important because over 70% of those experiencing a first Coronary Heart Disease (CHD) event in China died outside of the hospital setting1.

Primary prevention of CVD in China is a top priority especially lifestyle factors such as  smoking, diet, weight and increasing activity levels in order to reduce risk factors such as high blood pressure, high cholesterol and control diabetes2.

CVD risk assessment is an important way to identify those at high-risk in the Chinese population without current CVD. Specific risk assessment tools for the Chinese population have been developed based the Chinese Multi –provincial cohort study.

The 2012 China National Plan for Non-Communicable diseases [NCD] prevention and treatment3 has clear targets for CVD prevention.  The 2016 China guidelines of dyslipidemia management and the 2017 Chinese guidelines for CVD prevention have new recommendations for risk assessment in China.

The 2016 China expert consensus advocates that for individuals with a ten year arteriosclerotic cardiovascular disease (ASCVD)4 risk of greater than or equal to 10%, aspirin should be used for the primary prevention of CVD.

SECONDARY PREVENTION OF STROKE PREVENTION IN CHINA

The Chinese clinical guidelines for the secondary prevention of ischemic stroke and TIA recommend an optimal dosage of aspirin between 75 and 150 mg/day. A combination of aspirin and clopidogrel for 21 days is recommended for patients with minor stroke or high-risk TIA within 24 h of onset5. These recommendations are based on the CHANCE trial6.

REFERENCES CVD PREVENTION

1.Chin J Cardiol, March 2012; Vol 40 No 3.

2. Walker J, Hutchison P, Ge J et al 2018 Aspirin:120 years of innovation. A report from the 2017 Scientific Conference of the International Aspirin Foundation. ecancer 12 813 https://doi.org/10.3332/ecancer.2018.813 

3.China National Plan for NCD Prevention and Treatment (2012-2015). http://www.chinaede.en.en  [accessed June 14, 2014].

4.ASCVD http://tools.acc.org/ascvd-risk-estimator-plus/#!/calculate/estimate

5. Wang Y, Liu M and Pu C 2014 Chinese guidelines for secondary prevention of ischemic stroke and transient ischemic attack. Int J Stroke 2017; 12(3):302-320.

6.Wang Y, Pan Y, Zhao X et al Clopidogrel with Aspirin in Acute Minor Stroke or Transient Ischemic Attack (CHANCE) Trial: One-Year outcomes [j]. Circulation 2015; 132(1):40-46.