Farhat Din completed her medical degree at St Andrews and Manchester University prior to returning to Edinburgh to undertake surgical training. She completed her MD thesis in examining the molecular mechanisms underlying NSAID- mediated prevention of colorectal cancer. She was awarded a Cancer Research UK Clinician Scientist fellowship in 2010. Currently she integrates her clinical practice as a consultant colorectal surgeon with her translational research programme investigating the effects of aspirin and other chemopreventive agents on mTOR signalling in colorectal cancer.
Colorectal cancer is a major cause of cancer death worldwide necessitating new strategies of disease control. Understanding the cellular signalling that governs growth of cancer cells holds the key to developing agents which interfere with cancer proliferation. The mTOR signalling pathway plays a pivotal role in controlling cell survival and regulation of cell metabolism and energy balance. Dysregulation of the mTOR signalling axis is implicated in the development of several cancers including colorectal cancer, supporting mTOR signalling as a promising target for chemoprevention. Our research focuses on colorectal cancer prevention by investigating the molecular mechanisms of the anti-tumour effects of chemopreventive agents such as aspirin on mTOR signalling to identify druggable targets in a pathway medicine approach.