Professor of Pharmacology, Department of Neuroscience, Imaging and Clinical Sciences, Section of Cardiovascular and Pharmacological Sciences, "G. d’Annunzio" University, Chieti, Italy.
Paola Patrignani was graduated at the Faculty of Biological Sciences, "La Sapienza" University of Rome (Italy). Then, she followed a doctoral training in Pharmacology, at Catholic University of Rome, Italy. She worked for 2 years as Postdoctoral Research Fellow at Le Centre Hospitalier of Laval University (Quebec, Canada) and at the Department of Pharmacology of Merck Frosst (Kirkland, Quebec, Canada). She continued her academic career at “G. d' Annunzio” University, School of Medicine, Chieti, Italy, where she is currently Professor of Pharmacology and Head of the Research Unit of Pharmacology and Pharmacodynamics of eicosanoids at the Center of Excellence on Aging (CeSI). In 2009 she was Guest professor of Pharmacology at Goethe-Universität Frankfurt am Main (Germany). She is a member of the Italian Society of Pharmacology and she received the Upjohn Award (1981) and the "Henry Christian" Award (1991). In 2013, she received a special prize awarded by the Committee for the Promotion of Female Entrepreneurship of Abruzzo Region (Italy).
Her scientific activity is documented by 150 peer-reviewed publications in international journals ranked in the Journal Citation Reports, and 21 chapters in national-international books. Her cumulative citation index is 6797: the h index is 42.
Short statements of expertise:
- Her research focuses on the study of the role of eicosanoids in inflammation, cancer and cardiovascular disease.
- She has contributed to the development of biomarkers predictive of the impact of NSAIDs on COX-1 and COX-2 activities in vitro, ex vivo and in vivo which have been essential to read-out the clinical consequences of selective and nonselective inhibition of COX-isozymes in humans.
- Her recent studies have allowed to clarify the determinants of NSAID toxicity for the gastrointestinal and cardiovascular systems which will be important for the development of personalized treatments in humans.
- She is performing an intense research activity with the aim of identifying the mechanisms of the anti-tumorigenic effects of antiplatelet agents, with particular interest in clarifying the mechanism of action of aspirin. To realize these aims her research group is integrating basic and clinical research in different biological systems using the “Omics” approach.